A review of knowledge on the mechanisms of action of the rare sugar <scp>d</scp> ‐tagatose against phytopathogenic oomycetes

d-tagatose is a rare monosaccharide, naturally present at low concentrations in some fruits and dairy products. "generally recognized as safe" used low-calorie sweetener the food industry. It able to inhibit growth of numerous microorganisms, such phytopathogenic oomycetes responsible for important crop diseases. Thanks negligible effects on human health environment, has been proposed sustainable product protection. This review describes current knowledge modes action against its potential uses agriculture. can negatively affect by inhibiting key enzymes sugar metabolism, β-glucosidase Phytophthora infestans, fructokinase phosphomannose isomerase Hyaloperonospora arabidopsidis. Moreover, affects content, causes severe mitochondrial alterations, inhibits respiration processes with accumulation reactive oxygen species P. but not cinnamomi. Differential are associated global gene downregulation infestans an efficient transcriptional reprogramming multiple metabolic displays possible species-specific spp. nutritional properties plant-associated microorganisms. However, inhibitory reversible be restored absence d-tagatose. Further functional studies discussed this review, order promote use